Epigenetics
Overview
Virtually all 37.2 trillion cells in our bodies have the same DNA, the spiraling molecule that contains the genetic instructions required to make us who we are. But if every cell works from the same playbook, how and why does the human body have so many different types of cells? Why do some become skin cells while others become muscle cells, heart cells or brain cells?
The answer is epigenetics — a complex set of processes that determine when and to what extent certain genetic instructions are carried out. Epigenetic processes are vital for healthy cellular function and, when things go awry, they can play major roles in disease.
Scientists in VAI’s Department of Epigenetics seek to understand how epigenetic changes may either protect us from or predispose us to complex diseases such as cancer, Parkinson’s and metabolic disorders. By investigating the epigenetic processes that fine-tune DNA, our scientists aim to pinpoint the origins of these complex diseases and determine how they are impacted by our past, present and future.
Our Faculty
Xiaobing Shi, Ph.D.
Interim Chair and Professor, Department of Epigenetics
Histone Modifications and Chromatin Regulation
Stephen Baylin, M.D.
Co-leader, Van Andel Institute–Stand Up To Cancer Epigenetics Dream Team
Director’s Scholar and Professor, Department of Epigenetics
Yvonne Fondufe-Mittendorf, Ph.D.
Professor, Department of Epigenetics
Epigenetic Regulation and Environmental Impacts
Peter A. Jones, Ph.D., D.Sc. (hon)
Chief Scientific Officer; President, Van Andel Institute Graduate School
Epigenetic Therapies
Gerd Pfeifer, Ph.D.
Professor, Department of Epigenetics
Epigenetic and Genetic Pathways in Human Disease
J. Andrew Pospisilik, Ph.D.
Professor, Department of Epigenetics
Epigenetic Origins of Heterogeneity and Disease
Scott Rothbart, Ph.D.
Associate Professor, Department of Epigenetics
Chromatin and Epigenetic Regulation
Hui Shen, Ph.D.
Associate Professor, Department of Epigenetics
Epigenomics Analysis in Human Disease
Piroska Szabó, Ph.D.
Associate Professor, Department of Epigenetics
Developmental Programming
Tim Triche, Jr., Ph.D.
Associate Professor, Department of Epigenetics
Translational Biological Informatics
Hong Wen, Ph.D.
Associate Professor, Department of Epigenetics
Epigenetics and Transcription
