Liman Zhang, Ph.D. – VAI Seminar Series

Structural basis of bacterial detection by NAIP/NLRC4 inflammasome

Speaker Information

Liman Zhang, Ph.D.
Assistant Professor
Department of Chemical Physiology and Biochemistry
Oregon Health & Science University

• Abstract: Our innate immune system encodes multiple signal molecules to detect and respond to bacterial infection. Their proper activation is critical for pathogen clearance, however, they must remain silent in a steady state to prevent auto-inflammation. In this talk, we will discuss how NAIP/NLRC4, the bacterial sensing inflammasome, assembles upon gram-negative bacterial infection.
• Host: Postdoctoral Association, Tinghai Xu, Ph.D. postdoc host