Category:
Carcinomas
Cancer type:
Breast
Descriptor:
Therapeutic Development
Reference Number:
22
Jakubczak, J. L., LaRochelle, W. J. & Merlino, G. NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo.
Mol Cell Biol 18, 1275-83. (1998).
PubMed link
Reference Number:
23
Kuba, K. et al. HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice.
Cancer Res 60, 6737-43 (2000).
PubMed link
Reference Number:
222
Martin, T.A. et al. Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist. Carcinogenesis 24:1317-23 (2003).
PubMed link
Reference Number:
235
Jiang, WG, Grimshaw, D, Martin, TA, Davies, G, Parr, C, Watkins, G, Lane, J, Abounader, R, Laterra, J, Mansel, RE. Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET.
Clin Cancer Res 15:4274-81 (2003).
PubMed link
Reference Number:
294
Michieli P, Mazzone M, Basilico C, Cavassa S, Sottile A, Naldini L, Comoglio PM. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.
Cancer Cell 6, 61-73 (2004)
PubMed link
Reference Number:
295
Wright TG, Tsai J, Jia Z, Elliott BE. Inhibition by copper(II) binding of hepatocyte growth factor (HGF) interaction with its receptor Met and blockade of HGF/Met function.
J Biol Chem 279, 32499-506 (2004)
PubMed link
Reference Number:
342
Mazzone M, Basilico C, Cavassa S, Pennacchietti S, Risio M, Naldini L, Comoglio PM, Michieli P. An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice.
J Clin Invest. 114, 1418-32 (2004)
PubMed link
Reference Number:
511
Parr C, Jiang WG. Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells.
Int J Cancer.
119, 1176-83 (2006)
PubMed link
Reference Number:
545
Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, Koudriakova TB, Alton G, Cui JJ, Kung PP, Nambu MD, Los G, Bender SL, Mroczkowski B, Christensen JG. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.
Cancer Res.
67, 4408-17 (2007)
PubMed link
Reference Number:
635
Bonine-Summers AR, Aakre ME, Brown KA, Arteaga CL, Pietenpol JA, Moses HL, Cheng N. Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells.
Cancer Biol Ther.
6, 561-70 (2007)
PubMed link
Reference Number:
675
Yin YL, Chen HL, Kuo HM, He SP. NK3 and NK4 of HGF enhance filamin production via STAT pathway, but not NK1 and NK2 in human breast cancer cells.
Acta Pharmacol Sin. 29, 728-35 (2008)
PubMed link
Reference Number:
676
Syed DN, Afaq F, Sarfaraz S, Khan N, Kedlaya R, Setaluri V, Mukhtar H. Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation.
Toxicol Appl Pharmacol. 231, 52-60 (2008)
PubMed link
