Category:
Carcinomas
Cancer type:
Pancreas/Gall Bladder
Descriptor:
Therapeutic Development
Reference Number:
116
Maehara, N. et al. Gene transduction of NK4, HGF antagonist, inhibits in vitro invasion and in vivo growth of human pancreatic cancer.
Clin Exp Metastasis 19, 417-26 (2002).
PubMed link
Reference Number:
117
Saimura, M. et al. Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4.
Clin Cancer Res 8, 3243-9 (2002).
PubMed link
Reference Number:
118
Tomioka, D. et al. Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model.
Cancer Res 61, 7518-24 (2001).
PubMed link
Reference Number:
289
Lai RX, Yuan SZ, Nakamura T. [Article in Chinese] [Effect of Transferred NK4 Gene on Biological Characteristics of Human Pancreatic Cancer Cell Line SW1990.]
Ai Zheng 23, 1134-8 (2004)
PubMed link
Reference Number:
290
Kushibiki T, Matsumoto K, Nakamura T, Tabata Y. Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres.
Pharm Res 21, 1109-18 (2004)
PubMed link
Reference Number:
296
Ohuchida K, Mizumoto K, Murakami M, Qian LW, Sato N, Nagai E, Matsumoto K, Nakamura T, Tanaka M. Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions.
Cancer Res 64, 3215-22 (2004)
PubMed link
Reference Number:
297
Tanaka T, Shimura H, Sasaki T, Narumi K, Maemondo M, Nukiwa T, Matsumoto K, Nakamura T, Ikeda S. Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model.
Cancer Gene Ther 11, 431-40 (2004)
PubMed link
Reference Number:
389
Ogura Y, Mizumoto K, Nagai E, Murakami M, Inadome N, Saimura M, Matsumoto K, Nakamura T, Maemondo M, Nukiwa T, Tanaka M. Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival.
Cancer Gene Ther. 13, 520-9 (2006)
PubMed link
Reference Number:
390
Saito T, Tomida M. Generation of inhibitory DNA aptamers against human hepatocyte growth factor.
DNA Cell Biol. 24, 624-33 (2005)
PubMed link
Reference Number:
391
Bauer TW, Liu W, Fan F, Camp ER, Yang A, Somcio RJ, Bucana CD, Callahan J, Parry GC, Evans DB, Boyd DD, Mazar AP, Ellis LM. Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice.
Cancer Res. 65, 7775-81 (2005)
PubMed link
Reference Number:
628
Shah AN, Summy JM, Zhang J, Park SI, Parikh NU, Gallick GE. Development and characterization of gemcitabine-resistant pancreatic tumor cells.
Ann Surg Oncol.
14, 3629-37 (2007)
PubMed link
Reference Number:
648
Jin H, Yang R, Zheng Z, Romero M, Ross J, Bou-Reslan H, Carano RA, Kasman I, Mai E, Young J, Zha J, Zhang Z, Ross S, Schwall R, Colbern G, Merchant M. MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival.
Cancer Res.
68, 4360-8 (2008)
PubMed link
Reference Number:
673
Egami T, Ohuchida K, Mizumoto K, Onimaru M, Toma H, Nishio S, Nagai E, Matsumoto K, Nakamura T, Tanaka M. Radiation enhances adenoviral gene therapy in pancreatic cancer via activation of cytomegalovirus promoter and increased adenovirus uptake.
Clin Cancer Res.
14, 1859-67 (2008)
PubMed link
