Rederivation is used to establish Specific Pathogen Free (SPF) mice. We transfer preimplantation embryos into SPF pseudopregnant recipient females.
The efficiency of the rederivation procedure depends on the strain of mouse. Inbred strains require larger starting numbers of mice for a reasonable chance of success.
We require five or more superovulated, plugged females. To obtain these numbers, you will need a comparable number of individually housed stud males (5 or more). If only a couple of males or breeder pairs can be obtained, we will breed the animals up until we get the sufficient number of animals needed (this will be an additional per diem cost).
Standard rederivation includes comprehensive health monitoring (serology, bacteriology, parasitology, and pathology) to confirm the success of the rederivation procedure. Once the results are obtained, they will be sent to the veterinarian of the receiving facility to obtain approval for shipment. The entire process, from rederivation to shipment of animals, will take 10 to 12 weeks (depending on when health results are obtained).
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