Analytical, Cellular, and Molecular Microscopy
(Imaging, Histology and Diagnostic Pathology)
- Pathology services
- Tissue Resources
- Paraffin, frozen and plastic tissue processing
- Vibratome processing/sectioning
- Laser capture micro-dissection (Arcturus instrument)
- Laser scanning confocal imaging (Zeiss 510)
- Invivo intravital imaging using CRI Maestro
- Digital imaging
- Spectral deconvolution imaging
Animal Imaging Services
- BioScan CT/SPECT
- Ultrasound
- Olympus Stereodissecting Microscopy
Computational Biology
- Custom data analysis and consulting
- Niche program writing
- Assistance with computationally intensive tasks
Cryopreservation
Cytogenetics
- Fluorescent in-situ hybridization (FISH)
- Spectral karyotyping (SKY)
- Transgene localization
- G-banding
- Chromosomal breakage studies
- Trisomy 8 screening
Gene Targeting
- Electroporation of ES Cells, Clone Selection, and DNA Isolation
- Thawing and Expansion of ES Cell Clones
- Electroporation of Cre Recombinase
- Microinjection
- Tail Biopsy
- Tail DNA Isolation
- Preparation of Mouse Embryonic Fibroblasts
- Preparation of ES cell lines from blastocysts
- PCR analysis of blastocysts
- Cre-Lox Procedure
- Karyotyping
Microarray Technology
- Agilent Oligonucleotide Gene Expression Microarrays (customizable)
- ArrayCGH
- miRNA Expression Microarrays
- Microarray Data Analysis
- RNA Isolation and Amplification
- RNA Integrity Analysis (Agilent Bioanalyzer)
- DNA isolation and size/concentration analysis
- Spotted cDNA Microarray printing
- Custom Protein Microarray printing
Mouse Rederivation
- Includes comprehensive health monitoring (serology, bacteriology, parasitology, and pathology)
Mouse Transgenics
- DNA Construct Preparation
- Transgenics DNA Purification for Microinjection
- Transgenics Microinjection
- Tail Biopsies
Repository Services
Xenotransplantation
- Over- or underexpress gene(s) in established cell lines to validate their role in the etiology of tumors and their malignant progression
- Analysis and testing of therapeutics
