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Novel mechanisms of genetic instability in cancer Repetitive sequences have the capacity to adopt alternative DNA structures (e.g. H-DNA and Z-DNA) and stimulate genetic instability in the absence of exogenous DNA damage. However, the biological significance and the mechanisms of this DNA-structure-induced genetic instability are unknown. Here, we report that H-DNA- and Z-DNA-forming sequences are enriched at translocation breakpoints in human cancer genomes, implicating them in cancer etiology. We found that H-DNA-induced mutations were suppressed in human cells deficient in…Find out more »
PI 3-kinase and cancer metabolism Lewis Cantley, Ph.D., has made significant advances in cancer research stemming from his discovery of the signaling pathway phosphoinositide 3-kinase (PI3K) in 1984. The author of more than 400 original papers, 50 book chapters and review articles, Dr. Cantley is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Science, the Institute of Medicine of the National Academies, and the European life sciences academy EMBO. He…Find out more »
Have you ever wondered about what happens behind the scenes at VAI? Please join us for Behind the Scenes at Van Andel Institute to get an exclusive look. As a loyal supported of VAI, we are inviting you to this special virtual opportunity. Presentations from VAI leadership about the Institute’s work and how it impacts the lives of those with cancer and Parkinson’s disease will be featured. You’ll hear from David and Carol Van Andel, Dr. Peter A. Jones and…Find out more »
Title TBD Speaker Information Susanna Greer, Ph.D. Director, Clinical Cancer Research, Nutrition and Immunology American Cancer Society Time & Location 12:00 pm on Zoom VAI Host: Graduate Student Association, Katie Hollis Questions? For questions, please contact Kim Cousineau at 616.234.5684.Find out more »
The annual West Michigan Regional Undergraduate Science Research Conference (WMRUGS) brings together nearly 400 students and faculty for a day of learning and networking. Via virtual platform, students will share the story of their research project with other college students, faculty, research scientists and other college students, as well as build their network of peers with similar interests and experiences. Attendees will also hear stimulating talks on current topics in biology, biochemistry, bioinformatics, chemistry, computer science, engineering, geology, neuroscience, physics,…Find out more »
Join us for A Conversation About Depression — Hosted by Carol Van Andel, a fully virtual event that will discuss the biological underpinnings of depression and explore how a better understanding of the disorder can be translated into improved diagnostics and treatments. Guests will hear from West Michigan scientists working on the front lines of these efforts. No matter where you are in Michigan or beyond, join us for this powerful, virtual discussion focused on new ways of thinking about depression…Find out more »
Title TBD Speaker Information Sharona E. Gordon, Ph.D. Professor and Associate Dean for Research and Graduate Education University of Washington School of Medicine Time & Location 12:00 pm on Zoom VAI Host: Juan Du, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.Find out more »