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Van Andel Institute

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Van Andel Institute

333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

March 2019

Robert Roeder, Ph.D. – VARI Seminar Series

March 13, 2019 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Mechanisms of transcriptional regulation through diverse co-activators Transcriptional regulation by gene- and cell-specific DNA-binding factors underlies key events in development, cell differentiation and transformation. However, their effects on specific genes depend upon complex arrays of cofactors that include both chromatin modifying factors (e.g., histone acetyl-transferases and methyl-transferases) and other factors (e.g., Mediator and TAFs) that facilitate more direct communication between enhancer-bound regulatory factors and the general transcription machinery. Emphasizing biochemical studies with cell-free systems reconstituted with recombinant chromatin templates and…

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April 2019

David Gilbert, Ph.D. – VARI Seminar Series

April 17, 2019 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Regulation of replication timing and chromosome architecture Our goal is to understand how mammalian chromosomes are organized within the nucleus to carry out their functions. DNA replication provides an excellent forum in which to study chromosome structure and function. Structural and functional units of chromosomes replicate coordinately, often through the synchronous firing of clusters of replication origins that encompass domains of approximately 0.5 Mb. Each of these replication domains is programmed to replicate at a specific time during S-phase. In…

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May 2019

Brad Merrill, Ph.D. – VARI Seminar Series

May 1, 2019 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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THIS EVENT HAS BEEN CANCELLED.  Novel mechanisms controlling pluripotency of stem cells identified by genome editing approaches The early mammalian embryo traverses remarkably different environments before specification of somatic cell lineages occurs during gastrulation. Transitioning through different states of pluripotency is thought to provide cells a method of accommodating different conditions while they expand in numbers during the embryo’s journey. I will present some of our efforts to elucidate the mechanisms stem cells use to transition between states of pluripotency.…

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Bryan G. Allen, M.D., Ph.D. – VARI Seminar Series

May 15, 2019 @ 12:00 pm EDT - 1:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Manipulating metabolic oxidative stress to enhance cancer therapy Dr. Allen is an assistant professor and physician-scientist in the Department of Radiation Oncology at the University of Iowa. Dr. Allen is a redox biochemist with expertise in manipulating metabolic oxidative stress to enhance radiation and chemotherapy effectiveness and reduce associated treatment related toxicities. He is also a practicing radiation oncologist who participates in developing and running investigator initiated clinical trials. Speaker Information Bryan G. Allen, M.D., Ph.D. Tenure-Track Assistant Professor Department…

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June 2019

Margaret Goodell, Ph.D. – VARI Seminar Series

June 12, 2019 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Title TBD Speaker Information Margaret Goodell, Ph.D. Professor and Director, Stem Cells and Regenerative Medicine Center Vivian L. Smith Chair in Regenerative Medicine Co-Leader, Cancer Cell and Gene Therapy Baylor College of Medicine Time & Location 12:00 pm at Van Andel Institute Conference Room 3104/3105 VARI Host: Peter A. Jones, Ph.D., D.Sc. (hon) Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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David Sulzer, Ph.D. – VARI Seminar Series

June 19, 2019 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Multiple interactions between dopamine and alpha-synuclein Alpha-synuclein plays an important physiological function by inhibiting the exocytosis of synaptic vesicles but is also plays an instrumental role in the cause of Parkinson’s and additional diseases. We will discuss evidence suggesting how intracellular changes in the handling of this protein may initiate this disease and how it may lead to neuronal death including through steps in the acquired immune system. Speaker Information David Sulzer, Ph.D. Professor Departments of Psychiatry, Neurology, and Pharmacology…

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September 2019

VAI Symposium on Structural Biology

September 12, 2019 - September 13, 2019
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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The Van Andel Research Institute Symposium on Structural Biology will explore the latest advances in the fields of DNA-metabolizing enzymes and membrane proteins. The keynote address will be delivered by Dr. Xiaodong Cheng on Thursday, Sept. 12. A full day of lectures will follow on Friday, Sept. 13.

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Da-Neng Wang, Ph.D. – VAI Seminar Series

September 25, 2019 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Title TBD Speaker Information Da-Neng Wang, Ph.D. Professor, Department of Cell Biology NYU Medical School Time & Location 12:00 pm at Van Andel Institute Conference Room 3104/3105 VARI Host: Huilin Li, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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October 2019

VAI Scientific Vendor Expo

October 1, 2019 @ 10:30 am EDT - 2:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Van Andel Institute is hosting its second annual Scientific Vendor Expo and wants YOU to showcase your company's latest innovations. Join us on Tuesday, October 1, 2019 from 10:30 a.m. – 2:00 p.m. to network with researchers from Van Andel Institute, Michigan State University, Spectrum Health and Grand Valley State University. Attendees  Vendors  The cost is $250 per vendor and includes a table with linen, as well as lunch for the event. Reserve your spot before September 2, 2019 (space…

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Brian Strahl, Ph.D. – VAI Seminar Series

October 23, 2019 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Title TBD Speaker Information Brian Strahl, Ph.D. Vice-Chair, Department of Biochemistry and Biophysics University of North Carolina School of Medicine Time & Location 12:00 pm at Van Andel Institute Conference Room 3104/3105 VARI Host: Scott Rothbart, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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Satdarshan (Paul) Monga, M.D. – VAI Seminar Series

October 30, 2019 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Title TBD Speaker Information Satdarshan (Paul) Monga, M.D. Professor of Pathology Professor in Experimental Pathology University of Pittsburgh Time & Location 12:00 pm at Van Andel Institute Conference Room 3104/3105 VARI Host: Postdoctoral Association Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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November 2019

Midwest Metabolism Meeting

November 14, 2019 @ 10:45 am EST - November 15, 2019 @ 4:30 pm EST
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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The second Midwest Metabolism Meeting will highlight the latest advances in metabolism research and foster the growth of a collaborative network of scientists from the Midwest. The two-day meeting will kick off with a keynote address from Dr. Julie St.-Pierre from University of Ottawa, who will discuss advances in understanding cancer metastasis and therapeutic resistance using metabolomics. Sessions will delve into tumor metabolism; new advances in immunometabolism and impact on cancer and autoimmune disease; interactions between the metabolome and epigenetic…

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February 2020

Janelle Ayres, Ph.D. – VAI Seminar Series

February 12, 2020 @ 12:00 pm EST - 1:00 pm EST
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Host-microbe interactions: targeting co-evolution to treat disease Speaker Information Janelle Ayres, Ph.D. Professor Molecular and Systems Physiology Lab Gene Expression Laboratory Nomis Center for Immunobiology and Microbial Pathogenesis The Salk Institute for Biological Studies Time & Location 12:00 pm at Van Andel Institute Conference Room 3104/3105 VARI Host: Postdoctoral Association, Emmanuel Quansah, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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Jerry Workman, Ph.D. – VAI Seminar Series

February 26, 2020 @ 12:00 pm EST - 1:00 pm EST
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Nutritional stress signaling through chromatin Our laboratory has extensive experience in the purification and analysis of protein complexes that modify chromatin for gene expression. This includes both affinity purification techniques and conventional chromatography. Examples of complexes first purified in this laboratory include the SAGA complex from yeast the Tip60 complex from Drosophila and the Sin3 complex from mammalian cells. We have extensively analyzed the mammalian Sin3 deacetylase complexes in collaboration with the Washburn laboratory. We have collaborated extensively with the…

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September 2020

Grand Challenges in Parkinson’s Disease (Virtual)

September 23, 2020 - September 25, 2020
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Grand Challenges in Parkinson’s Disease brings together hundreds of scientists, clinicians and people with Parkinson’s to explore the latest Parkinson’s disease research. The theme for 2020 is When and How Does Parkinson’s Start?, which will focus on the origins and development of Parkinson’s, from potential triggers through the early symptoms and stages of the disease. Van Andel Institute and The Cure Parkinson’s Trust are thrilled to once again host Rallying to the Challenge, a meeting designed for and by people with Parkinson’s,…

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June 2021

Thomas Montine, M.D., Ph.D. – Jay Van Andel Seminar Series

June 30, 2021 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

“Synaptopathology in Alzheimer’s and Parkinson’s diseases” Dr. Montine received his education at Columbia University (BA in Chemistry), the University of Rochester (PhD in Pharmacology), and McGill University (MD and CM). His postgraduate medical training was at Duke University, and he was junior faculty at Vanderbilt University where he was awarded the Thorne Professorship in Pathology. In 2002, Dr. Montine was appointed as the Alvord Endowed Professor in Neuropathology and Director of the Division of Neuropathology at the University of Washington.…

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October 2021

Postdoc Preview

October 14, 2021 - October 16, 2021
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

Are you a senior graduate student exploring your postdoc options? VAI Postdoc Preview is a three-day program that provides selected applicants the opportunity to visit Van Andel Institute to learn about our postdoctoral training opportunities, meet one-on-one with our internationally recognized faculty and explore our extensive scientific resources, including our state-of-the-art Core Technologies and Services. This year’s Preview will be held Thursday, Oct. 14 through Saturday, Oct. 16. The application period is now closed. There is no cost to attend.…

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December 2021

Wentian Yang, M.D., Ph.D. – VAI Seminar Series

December 1, 2021 @ 12:00 pm EST
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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The roles of PTPN11 in skeletal development and diseases Dr. Yang received his M.D. from Lanzhou University School of Medicine and his Ph.D. in Molecular Biology from Sichuan University in China. After completing a postdoctoral fellowship with Dr. Benjamin Neel at Harvard University, he joined the Department of Orthopaedics at Brown University as a faculty member in 2007. Dr. Yang has received several honors and awards and currently serves on several professional research and education committees. Dr. Yang’s research focuses…

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March 2022

Pietro De Camilli, Ph.D. – Jay Van Andel Seminar Series

March 9 @ 12:00 pm EST - 1:00 pm EST
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

Lipid dynamics, Membrane contact sites and neurodegeneration De Camilli earned his M.D. from the University of Milano and was a postdoctoral fellow at Yale. After a brief return to Italy, he moved back to Yale in 1988 where he is currently Professor of Cell Biology and of Neuroscience. He served as Chair of the Department of Cell Biology (1997-2000) and of the Department of Neuroscience (2015-2021) and in 2005 co-founded the Yale Program in Cellular Neuroscience, Neurodegeneration and Repair. Since…

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Johnathan Whetstine, M.D., Ph.D. – VAI Seminar Series

March 16 @ 12:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

Epigenetics: A gatekeeper to DNA replication, amplification and drug response My laboratory studies how the chromatin microenvironment regulates gene expression while maintaining a stable genome. We have initiated these types of studies by focusing on a specific class of chromatin regulators, JmjC-containing histone demethylases. Since their discovery, my laboratory has been screening both solid and hematopoietic cancer for genomic anomalies in this class of enzymes. We have uncovered the first enzyme (KDM4A- histone tri-demethylase) responsible for generating site-specific DNA copy…

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April 2022

Ting Wang, Ph.D. – VAI Seminar Series

April 6 @ 12:00 pm EDT - 1:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

Transposable elements and epigenome evolution Dr. Ting Wang is the inaugural Sanford C. and Karen P. Loewentheil Distinguished Professor of Medicine at Washington University School of Medicine in St. Louis. Dr. Wang is an internationally recognized geneticist for his research on genetic and epigenetic impact of transposable element (TE) on gene regulation. His group is known for defining the widespread contribution of TEs to the evolution of species-specific gene regulatory networks as well as to the conservation of 3D genome…

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Julie Andersen, Ph.D. – Jay Van Andel Seminar Series

April 13 @ 12:00 pm EDT - 1:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

Title TBD Speaker Information Julie Andersen, Ph.D. Buck Institute Time & Location 12:00 p.m. in Conference Room 3104/3015. VAI Host: Darren Moore, Ph.D. Questions? For questions, please contact Courtney Zirkle at 616.234.5821.

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May 2022

Yi Xing, Ph.D. – VAI Seminar Series

May 4 @ 12:00 pm EDT - 1:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

Title TBD Speaker Information Yi Xing, Ph.D. University of Pennsylvania Time & Location 12:00 p.m. in Conference Room 3104/3015. VAI Host: Hui Shen, Ph.D. Questions? For questions, please contact Courtney Zirkle at 616.234.5821.

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Jolanta Grembecka, Ph.D. – VAI Seminar Series

May 11 @ 12:00 pm EDT - 1:00 pm EDT
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

Title TBD Speaker Information Jolanta Grembecka, Ph.D. University of Michigan Time & Location 12:00 p.m. in Conference Room 3104/3015. VAI Host: Hong Wen, Ph.D. Questions? For questions, please contact Courtney Zirkle at 616.234.5821.

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