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UID:35659-1788868800-1788872400@www.vai.org
SUMMARY:James Nuñez\, Ph.D. – VAI Seminar Series
DESCRIPTION:Editing the human epigenome with CRISPR\nGeneral approaches for heritably altering gene expression advances scientific discoveries and therapeutic efforts to manage and treat diseases. An emerging platform for gene perturbation is CRISPR epigenetic editing – technologies that enable locus-specific rewriting of DNA methylation and histone modifications. I will present our recent advances in developing new CRISPR epigenetic editing technologies\, specifically our CRISPRoff platforms that program long-term gene silencing across thousands of human genes. Using CRISPRoff as a platform to follow the establishment of heterochromatin de novo in cells\, I will present our unpublished data that link repressive histone marks and DNA methylation with RNA modifications to program epigenetic silencing of transposable elements. Our work advances technologies for site-specific editing of epigenetic modifications while opening biological insights into RNA-mediated establishment of epigenetic programs in human cells. \nSpeaker Information:\nJames Nuñez\, Ph.D.\nUniversity of California \nHost:\nMitchell Roth\, Ph.D. and the T32 Program \nIf you’d like to learn more about Dr. Nuñez and his research\, please visit: https://vcresearch.berkeley.edu/faculty/james-nunez
URL:https://www.vai.org/event/james-nunez-ph-d-vai-seminar-series/
LOCATION:Van Andel Institute\, 333 Bostwick Ave. NE\, Grand Rapids\, MI\, 49503\, United States
CATEGORIES:Scientific Events,Seminars
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