Category:
Carcinomas
Cancer type:
Breast
Descriptor:
Animal model
Reference Number:
19
Fan, S. et al. Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents.
Oncogene 17, 131-41 (1998).
PubMed link
Reference Number:
20
Farinelle, S. et al. Characterization of biological features and chemosensitivity of a new experimental lung metastasis model originating from the MXT mouse mammary adenocarcinoma.
Anticancer Res 19, 1171-80 (1999).
PubMed link
Reference Number:
21
Firon, M. et al. Dominant negative Met reduces tumorigenicity-metastasis and increases tubule formation in mammary cells.
Oncogene 19, 2386-97 (2000).
PubMed link
Reference Number:
24
Lamszus, K. et al. Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mammary fat pads of nude mice.
Lab Invest 76, 339-53 (1997).
PubMed link
Reference Number:
25
Liang, T. J., Reid, A. E., Xavier, R., Cardiff, R. D. & Wang, T. C. Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.
J Clin Invest 97, 2872-7 (1996).
PubMed link
Reference Number:
26
Rosen, E. M. et al. Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor.
Int J Cancer 57, 706-14 (1994).
PubMed link
Reference Number:
27
Shaharabany, M. et al. In vivo molecular imaging of met tyrosine kinase growth factor receptor activity in normal organs and breast tumors.
Cancer Res 61, 4873-8 (2001).
PubMed link
Reference Number:
28
Takayama, H. et al. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor.
Proc Natl Acad Sci U S A 94, 701-6 (1997).
PubMed link
Reference Number:
217
Gallego, M.I., Bierie, B. & Henninghausen, L. Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways.
Oncogene 22:8498-508 (2003).
PubMed link
Reference Number:
294
Michieli P, Mazzone M, Basilico C, Cavassa S, Sottile A, Naldini L, Comoglio PM. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.
Cancer Cell 6, 61-73 (2004)
PubMed link
Reference Number:
342
Mazzone M, Basilico C, Cavassa S, Pennacchietti S, Risio M, Naldini L, Comoglio PM, Michieli P. An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice.
J Clin Invest. 114, 1418-32 (2004)
PubMed link
Reference Number:
345
Shinomiya N, Gao CF, Xie Q, Gustafson M, Waters DJ, Zhang YW, Vande Woude GF. RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival.
Cancer Res.
64, 7962-70 (2004)
PubMed link
Reference Number:
346
Welm AL, Kim S, Welm BE, Bishop JM. MET and MYC cooperate in mammary tumorigenesis.
Proc Natl Acad Sci U S A. 102, 4324-9 (2005)
PubMed link
Reference Number:
358
Khoury H, Naujokas MA, Zuo D, Sangwan V, Frigault MM, Petkiewicz S, Dankort DL, Muller WJ, Park M. HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion.
Mol Biol Cell. 16 550-61(2005)
PubMed link
Reference Number:
365
Bertotti A, Comoglio PM, Trusolino L. Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.
Cancer Res. 65, 10674-9 (2005)
PubMed link
Reference Number:
368
Smolen GA, Muir B, Mohapatra G, Barmettler A, Kim WJ, Rivera MN, Haserlat SM, Okimoto RA, Kwak E, Dahiya S, Garber JE, Bell DW, Sgroi DC, Chin L, Deng CX, Haber DA. Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis.
Cancer Res. 66, 3452-5 (2006)
PubMed link
Reference Number:
463
Jiang WG, Davies G, Martin TA, Parr C, Watkins G, Mansel RE, Mason MD. The potential lymphangiogenic effects of hepatocyte growth factor/scatter factor in vitro and in vivo.
Int J Mol Med. 16, 723-8 (2005)
PubMed link
