Category:
Carcinomas
Cancer type:
Breast
Descriptor:
In vitro studies
Reference Number:
13
Beviglia, L., Matsumoto, K., Lin, C. S., Ziober, B. L. & Kramer, R. H. Expression of the c-Met/HGF receptor in human breast carcinoma: correlation with tumor progression.
Int J Cancer 74, 301-9. (1997).
PubMed link
Reference Number:
17
Elliott, B. E., Hung, W. L., Boag, A. H. & Tuck, A. B. The role of hepatocyte growth factor (scatter factor) in epithelial-mesenchymal transition and breast cancer.
Can J Physiol Pharmacol 80, 91-102 (2002).
PubMed link
Reference Number:
18
Jiang, W. G. et al. A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells.
Clin Cancer Res 7, 2555-62 (2001).
PubMed link
Reference Number:
236
Nicola MH, Bizon R, Machado JJ, Sollero T, Rodarte RS, Nobre JS, Magalhaes MM, Takiya CM, Borojevic R. Breast cancer micrometastases: different interactions of carcinoma cells with normal and cancer patients' bone marrow stromata.
Clin Exp Metastasis 20:471-9 (2003).
PubMed link
Reference Number:
309
Tacchini L, De Ponti C, Matteucci E, Follis R, Desiderio MA. Hepatocyte growth factor-activated NF-{kappa}B regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines.
Carcinogenesis 25, 2089-2100 (2004)
PubMed link
Reference Number:
310
Martin TA, Watkins G, Mansel RE, Jiang WG. Hepatocyte growth factor disrupts tight junctions in human breast cancer cells.
Cell Biol Int 28, 361-71 (2004)
PubMed link
Reference Number:
312
Zhang YW, Su Y, Volpert OV, Vande Woude GF. Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation.
Proc Natl Acad Sci USA 100, 12718-23 (2003)
PubMed link
Reference Number:
358
Khoury H, Naujokas MA, Zuo D, Sangwan V, Frigault MM, Petkiewicz S, Dankort DL, Muller WJ, Park M. HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion.
Mol Biol Cell. 16 550-61(2005)
PubMed link
Reference Number:
359
Matteucci E, Locati M, Desiderio MA. Hepatocyte growth factor enhances CXCR4 expression favoring breast cancer cell invasiveness.
Exp Cell Res. 310 176-85 (2005)
PubMed link
Reference Number:
365
Bertotti A, Comoglio PM, Trusolino L. Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.
Cancer Res. 65, 10674-9 (2005)
PubMed link
Reference Number:
367
Singletary K, Ellington A. Genistein suppresses proliferation and MET oncogene expression and induces EGR-1 tumor suppressor expression in immortalized human breast epithelial cells.
Anticancer Res. 26, 1039-48 (2006)
PubMed link
Reference Number:
368
Smolen GA, Muir B, Mohapatra G, Barmettler A, Kim WJ, Rivera MN, Haserlat SM, Okimoto RA, Kwak E, Dahiya S, Garber JE, Bell DW, Sgroi DC, Chin L, Deng CX, Haber DA. Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis.
Cancer Res. 66, 3452-5 (2006)
PubMed link
Reference Number:
404
Bigelow RL, Cardelli JA. The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells.
Oncogene. 25, 1922-30 (2006)
PubMed link
Reference Number:
435
Wojcik EJ, Sharifpoor S, Miller NA, Wright TG, Watering R, Tremblay EA, Swan K, Mueller CR, Elliott BE. A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells.
Oncogene. 25, 2773-84 (2006)
PubMed link
Reference Number:
463
Jiang WG, Davies G, Martin TA, Parr C, Watkins G, Mansel RE, Mason MD. The potential lymphangiogenic effects of hepatocyte growth factor/scatter factor in vitro and in vivo.
Int J Mol Med. 16, 723-8 (2005)
PubMed link
Reference Number:
464
Stuelten CH, DaCosta Byfield S, Arany PR, Karpova TS, Stetler-Stevenson WG, Roberts AB. Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta.
J Cell Sci. 118, 2143-53 (2005)
PubMed link
Reference Number:
484
Parr C, Jiang WG. Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells.
Int J Cancer.
119, 1176-83 (2006)
PubMed link
Reference Number:
499
Bonine-Summers AR, Aakre ME, Brown KA, Arteaga CL, Pietenpol JA, Moses HL, Cheng N. Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells.
Cancer Biol Ther.
6, 561-70 (2007)
PubMed link
Reference Number:
544
Matteucci E, Ridolfi E, Desiderio MA. Hepatocyte growth factor differently influences Met-E-cadherin phosphorylation and downstream signaling pathway in two models of breast cells.
Cell Mol Life Sci.
63, 2016-26 (2006)
PubMed link
Reference Number:
545
Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, Koudriakova TB, Alton G, Cui JJ, Kung PP, Nambu MD, Los G, Bender SL, Mroczkowski B, Christensen JG. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.
Cancer Res.
67, 4408-17 (2007)
PubMed link
Reference Number:
554
Filigheddu N, Cutrupi S, Porporato PE, Riboni F, Baldanzi G, Chianale F, Fortina E, Piantanida P, De Bortoli M, Vacca G, Graziani A, Surico N. Diacylglycerol kinase is required for HGF-induced invasiveness and anchorage-independent growth of MDA-MB-231 breast cancer cells.
Anticancer Res.
27, 1489-92 (2007)
PubMed link
Reference Number:
575
Pozner-Moulis S, Pappas DJ, Rimm DL. Met, the hepatocyte growth factor receptor, localizes to the nucleus in cells at low density.
Cancer Res.
66, 7976-82 (2006)
PubMed link
Reference Number:
594
Shattuck DL, Miller JK, Laederich M, Funes M, Petersen H, Carraway KL 3rd, Sweeney C. LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy.
Mol Cell Biol.
27, 1934-46 (2007)
PubMed link
Reference Number:
610
Lee WJ, Chen WK, Wang CJ, Lin WL, Tseng TH. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells.
Toxicol Appl Pharmacol.
226, 178-91 (2007)
PubMed link
Reference Number:
615
Matteucci E, Ridolfi E, Maroni P, Bendinelli P, Desiderio MA. c-Src/histone deacetylase 3 interaction is crucial for hepatocyte growth factor dependent decrease of CXCR4 expression in highly invasive breast tumor cells.
Mol Cancer Res.
5, 833-45 (2007)
PubMed link
Reference Number:
675
Yin YL, Chen HL, Kuo HM, He SP. NK3 and NK4 of HGF enhance filamin production via STAT pathway, but not NK1 and NK2 in human breast cancer cells.
Acta Pharmacol Sin. 29, 728-35 (2008)
PubMed link
Reference Number:
689
Cheng N, Chytil A, Shyr Y, Joly A, Moses HL. Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion.
Mol Cancer Res.
6, 1521-33 (2008)
PubMed link
Reference Number:
697
Ridolfi E, Matteucci E, Maroni P, Desiderio MA. Inhibitory effect of HGF on invasiveness of aggressive MDA-MB231 breast carcinoma cells, and role of HDACs.
Br J Cancer.
99, 1623-34. Epub 2008 Oct 21 (2008)
PubMed link
