Category:
Carcinomas
Cancer type:
Liver
Descriptor:
Animal model
Reference Number:
22
Jakubczak, J. L., LaRochelle, W. J. & Merlino, G. NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo.
Mol Cell Biol 18, 1275-83. (1998).
PubMed link
Reference Number:
79
Amicone, L. et al. Synergy between truncated c-Met (cyto-Met) and c-Myc in liver oncogenesis: importance of TGF-beta signalling in the control of liver homeostasis and transformation.
Oncogene 21, 1335-45 (2002).
PubMed link
Reference Number:
80
Bell, A., Chen, Q., DeFrances, M. C., Michalopoulos, G. K. & Zarnegar, R. The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice.
Oncogene 18, 887-95 (1999).
PubMed link
Reference Number:
81
Horiguchi, N. et al. Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine.
Oncogene 21, 1791-9 (2002).
PubMed link
Reference Number:
82
Nakayama, N. et al. Hepatocyte growth factor and c-met expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma.
Hepatology 24, 596-602. (1996).
PubMed link
Reference Number:
83
Price, J. A. et al. .
Hepatology 36, 1089-97. (2002).
PubMed link
Reference Number:
84
Sakata, H. et al. Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers.
Cell Growth Differ 7, 1513-23 (1996).
PubMed link
Reference Number:
85
Santoni-Rugiu, E. et al. Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model.
Proc Natl Acad Sci U S A 93, 9577-82. (1996).
PubMed link
Reference Number:
86
Shiota, G., Kawasaki, H., Nakamura, T. & Schmidt, E. V. Inhibitory effect of hepatocyte growth factor on metastasis of hepatocellular carcinoma in transgenic mice.
Res Commun Mol Pathol Pharmacol 91, 33-9 (1996).
PubMed link
Reference Number:
251
Scarpino S, D'Alena FC, Di Napoli A, Ballarini F, Prat M, Ruco LP. Papillary carcinoma of the thyroid: evidence for a role for hepatocyte growth factor (HGF) in promoting tumour angiogenesis.
J Pathol 199:243-50 (2003).
PubMed link
Reference Number:
344
Boccaccio C, Sabatino G, Medico E, Girolami F, Follenzi A, Reato G, Sottile A, Naldini L, Comoglio PM. The MET oncogene drives a genetic programme linking cancer to haemostasis. Nature
434, 396-400 (2005)
PubMed link
Reference Number:
399
Lasagna N, Fantappie O, Solazzo M, Morbidelli L, Marchetti S, Cipriani G, Ziche M, Mazzanti R. Hepatocyte growth factor and inducible nitric oxide synthase are involved in multidrug resistance-induced angiogenesis in hepatocellular carcinoma cell lines.
Cancer Res. 66, 2673-82 (2006)
PubMed link
Reference Number:
403
Zhang SZ, Pan FY, Xu JF, Yuan J, Guo SY, Dai G, Xue B, Shen WG, Wen CJ, Zhao DH, Li CJ. Knockdown of c-Met by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo.
Mol Cancer Ther. 4, 1577-84 (2005)
PubMed link
Reference Number:
469
Jo J, Yamamoto M, Matsumoto K, Nakamura T, Tabata Y. Liver targeting of plasmid DNA with a cationized pullulan for tumor suppression.
J Nanosci Nanotechnol.
6, 2853-9 (2006)
PubMed link
Reference Number:
471
Tward AD, Jones KD, Yant S, Kay MA, Wang R, Bishop JM. Genomic progression in mouse models for liver tumors.
Cold Spring Harb Symp Quant Biol. 70, 217-24 (2005)
PubMed link
Reference Number:
472
Son G, Hirano T, Seki E, Iimuro Y, Nukiwa T, Matsumoto K, Nakamura T, Fujimoto J. Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice.
J Hepatol.
45, 688-95 (2006)
PubMed link
Reference Number:
474
Nakanishi C, Moriuchi A, Ido A, Numata M, Kim ID, Kusumoto K, Hasuike S, Abe H, Nagata K, Akiyama Y, Uto H, Kataoka H, Tsubouchi H. Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats fed a choline-deficient L-amino acid-defined diet.
Oncol Rep.
16 25-31 (2006)
PubMed link
Reference Number:
497
Son G, Hirano T, Seki E, Iimuro Y, Nukiwa T, Matsumoto K, Nakamura T, Fujimoto J. Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice.
J Hepatol.
45, 688-95 (2006)
PubMed link
Reference Number:
540
Yoshida Y, Hirano T, Son G, Iimuro Y, Imado T, Iwasaki T, Fujimoto J. Allogeneic bone marrow transplantation for hepatocellular carcinoma: hepatocyte growth factor suppresses graft-vs.-host disease.
Am J Physiol Gastrointest Liver Physiol.
293, G1114-23 (2007)
PubMed link
Reference Number:
558
Meredith K, Haemmerich D, Qi C, Mahvi D. Hepatic resection but not radiofrequency ablation results in tumor growth and increased growth factor expression.
Ann Surg.
245, 771-6 (2007)
PubMed link
Reference Number:
573
Isbert C, Ritz JP, Roggan A, Schuppan D, Ajubi N, Buhr HJ, Hohenberger W, Germer CT. Laser-induced thermotherapy (LITT) elevates mRNA expression of connective tissue growth factor (CTGF) associated with reduced tumor growth of liver metastases compared to hepatic resection.
Lasers Surg Med.
39, 42-50 (2007)
PubMed link
Reference Number:
600
Kopitz C, Gerg M, Bandapalli OR, Ister D, Pennington CJ, Hauser S, Flechsig C, Krell HW, Antolovic D, Brew K, Nagase H, Stangl M, von Weyhern CW, Brücher BL, Brand K, Coussens LM, Edwards DR, Krüger A. Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.
Cancer Res. 67, 8615-23 (2007)
PubMed link
Reference Number:
611
Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R, Bishop JM. Distinct pathways of genomic progression to benign and malignant tumors of the liver.
Proc Natl Acad Sci U S A. 104, 14771-6 (2007)
PubMed link
Reference Number:
632
Takami T, Kaposi-Novak P, Uchida K, Gomez-Quiroz LE, Conner EA, Factor VM, Thorgeirsson SS. Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Cancer Res.
67, 9844-51 (2007)
PubMed link
Reference Number:
633
Towner RA, Smith N, Tesiram YA, Abbott A, Saunders D, Blindauer R, Herlea O, Silasi-Mansat R, Lupu F. In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging.
Mol Imaging.
6, 18-29 (2007)
PubMed link
Reference Number:
644
Takashima K, Ito Y, Gonzalez FJ, Nakajima T. Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice.
J Occup Health.
50, 169-80 (2008)
PubMed link
Reference Number:
663
Takahara T, Xue F, Mazzone M, Yata Y, Nonome K, Kanayama M, Kawai K, Pisacane AM, Takahara S, Li XK, Comoglio PM, Sugiyama T, Michieli P. Metron factor-1 prevents liver injury without promoting tumor growth and metastasis.
Hepatology.
47, 2010-25 (2008)
PubMed link
Reference Number:
684
Huh CG, Factor VM, Sánchez A, Uchida K, Conner EA, Thorgeirsson SS. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair.
Proc Natl Acad Sci U S A. 101, 4477-82 (2004)
PubMed link
