Hepatocyte Growth Factor / Scatter Factor (HGF/SF), MET and cancer references
Yes = Click to view links to PubMed abstracts addressing specific cancer types.
*= Click to view links to PubMed abstracts addressing general categories of cancer.
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Category Cancer Type HGF/SF expression Met expression Poor Prognosis Mutation of Met In vitro studies Animal models Therapeutic Development Reviews
Carcinomas   * * * * * * * *
  Bladder Yes Yes Yes Yes Yes Yes
  Breast Yes Yes Yes Yes Yes Yes Yes Yes
  Cervical Yes Yes Yes Yes Yes
  Cholangiocarcinoma Yes Yes Yes Yes Yes Yes Yes
  Colorectal Yes Yes Yes Yes Yes Yes Yes Yes
  Endometrial Yes Yes Yes Yes Yes
  Esophogeal Yes Yes Yes Yes Yes Yes
  Gastric Yes Yes Yes Yes Yes Yes Yes Yes
  Head and Neck Yes Yes Yes Yes Yes Yes Yes Yes
  Kidney Yes Yes Yes Yes Yes Yes Yes Yes
  Liver Yes Yes Yes Yes Yes Yes Yes Yes
  Lung Yes Yes Yes Yes Yes Yes Yes Yes
  Nasopharyngeal Yes Yes Yes Yes Yes
  Ovarian Yes Yes Yes Yes Yes Yes Yes Yes
  Pancreas/Gall Bladder Yes Yes Yes Yes Yes Yes
  Prostate Yes Yes Yes Yes Yes Yes Yes
  Thyroid Yes Yes Yes Yes Yes Yes Yes
Musculoskeletal sarcomas   * * *
  Osteosarcoma Yes Yes Yes Yes Yes Yes
  Rhabdomyosarcoma Yes Yes Yes Yes Yes Yes
  Synovial Sarcoma Yes Yes Yes Yes
Soft tissue sarcomas   * * * *
  Kaposi's Sarcoma Yes Yes Yes Yes Yes
  Leiomyosarcoma Yes Yes Yes Yes Yes Yes
  MFH/Fibrosarcoma Yes Yes Yes Yes Yes
Hematopoietic Malignancies  
  Acute Myelogenous Leukemia Yes Yes
  Adult T Cell Leukemia Yes Yes Yes Yes Yes
  Chronic Myeloid Leukemia Yes Yes Yes Yes
  Lymphomas Yes Yes Yes Yes Yes Yes Yes Yes
  Multiple Myeloma Yes Yes Yes Yes Yes Yes Yes
Other Neoplasms   *
  Glioblastomas/Astrocytomas Yes Yes Yes Yes Yes Yes Yes Yes
  Melanoma Yes Yes Yes Yes Yes
  Mesothelioma Yes Yes Yes Yes Yes Yes Yes Yes
  Wilms' Tumor Yes Yes Yes Yes

For each cancer type, headings corresponding to studies showing: HGF/SF expression in tumour biopsies; Met expression in tumour biopsies; expression of HGF/SF or Met correlating with poor prognosis; sporadic or germline-activating mutations in Met; tumour cells expressing Met or HGF/SF in vitro; animal models supporting the role of Met and HGF/SF in cancer, including human tumour xenografts in immunecompromised mice, mice with HGF/SF or Met transgenes, or other animal models displaying dependence on HGF/SF or Met in cancer development; therapeutic developments; HGF/SF-MET Reviews; Clicking the column or row headings will display all appropriate references for the chosen category or cancer type.

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