Selected Publications
Furge, K., J.P. MacKeigan, and B. Teh. In press. Kinase targets in renal cell carcinomas: reevaluating the old and discovering the new. Lancet Oncology.
Schaeffer, E.M., T.J. Guzzo, K. Furge, G. Netto, M. Westphal, K. Dykema, X.J. Yang, M. Zhou, B. Teh, and C.P. Pavlovich. In press. Renal medullary carcinoma: molecular, pathologic and clinical evidence for treatment with topoisomerase inhibiting therapy. British Journal of Urology International. PubMed Article
Tan, M.H., K. Ravindran, H. Li, H.L. Tan, P.-H. Tan, C.F. Wong, K.S. Chia, B. Teh, J. Yuen, and T.W. Chong. In Press. A comparison of the UCLA Integrated Stating System (UISS) and the Leibovich scores in survival prediction for patients with non-metastatic clear cell renal cell carcinoma. Urology. Published online before print, December 16, 2009. PubMed Article
Bignell, G.R., C.D. Greenman, H. Davies, A.P. Butler, S. Edkins, J.M. Andrews, G. Buck, L. Chen, D. Beare, C. Latimer, S. Widaa, J. Hinton, C. Fahey, B. Fu, S. Swamy, G.L. Dalgliesh, B.T. Teh, P. Deloukas, F. Yang, P.J. Campbell, P.A. Futreal, and M.R. Stratton. 2010. Signatures of mutation and selection in the cancer genome. Nature 463(7283): 893–898. PubMed Article
Dalgliesh, G.L., K. Furge, C. Greenman, L. Chen, G. Bignell, A. Butler, H. Davies, S. Edkins, C. Hardy, C. Latimer, et al. 2010. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463(7279): 360-363. PubMed Article
Farber, L., E. Kort, P.F. Wang, J. Chen, and B. Teh. 2010. The tumor suppressor parafibromin is required for posttranscriptional processing of histone mRNA. Mol. Carcinog. 49(3): 215–223. PubMed Article
Hahn, M.A., V.M. Howell, A.J. Gill, A. Clarkson, G. Weaire-Buchanan, B.G. Robinson, L. Delbridge, O. Gimm, W.D. Schmitt, B.T. Teh, and D.J. Marsh. 2010. CDC73/HRPT2 CpG island hypermethylation and mutation of 5'-untranslated sequence are uncommon mechanisms of silencing parafibromin in parathyroid tumors. Endocr. Relat. Cancer 17(1): 273–282. PubMed
Huang, D., Y. Ding, Y. Li, W.-M. Luo, Z.-F. Zhang, J. Snider, K. VandenBeldt, C.-N. Qian, and B.T. Teh. 2010. Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma. Cancer Res. 70(3): 1053–1062. PubMed Article
Huang, D., Y. Ding, M. Zhou, B.I. Rini, D. Petillo, C.-N. Qian, R. Kahnoski, P.A. Futreal, K.A. Furge, and B.T. Teh. 2010. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Research 70(3): 1063–1071. PubMed Article
Furge, K.A., and B.T. Teh. 2009. Genetics of sporadic renal cell carcinoma. In Renal Cell Carcinoma, B.I. Rini and S.C. Campbell, eds. Clinical Oncology series, Shelton, Connecticut: People's Medical Publishing House, pp. 41–50.
Howell, V.M., A. Gill, A. Clarkson, A.E. Nelson, R. Dunne, L.W. Delbridge, B.G. Robinson, B.T. Teh, O. Gimm, and D.J. Marsh. 2009. Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma. J. Clin. Endocrinol. Metab. 94(2): 434–441. PubMed Article
Hui, Z., M. Tretiakova, Z. Zhang, Y. Li, X. Wang, J.X. Zhu, Y. Gao, W. Mai, K. Furge, C.-N. Qian, R. Amato, E.B. Butler, B.T. Teh, and B.S. Teh. 2009. Radiosensitization by inhibiting STAT1 in renal cell carcinoma. International Journal of Radiation Oncology Biology Physics 73(1): 288–295. PubMed Article
Khoo, S.K., R. Pendek, R. Nickolov, D.C. Luccio-Camelo, T.L. Newton, A. Massie, D. Petillo, J. Menon, D. Cameron, B.T. Teh, and S.-P. Chan. 2009. Genome-wide scan identifies novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma. Endocr. Relat. Cancer 16(3): 1057–1063. PubMed
Macher-Goeppinger, S., S. Aulmann, K.E. Tagscherer, N. Wagener, A. Haferkamp, R. Penzel, A. Brauckhoff, M. Hohenfellner, J. Sykora, H. Walczak, B.T. Teh, F. Autschbach, E. Herpel, P. Schirmacher, and W. Roth. 2009. Prognostic value of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and TRAIL receptors in renal cell cancer. Clin. Cancer Res. 15(2): 650–659. PubMed
Petillo, D., E.J. Kort, J. Anema, K.A. Furge, X.J. Yang, and B.T. Teh. 2009. MicroRNA profiling of human kidney cancer subtypes. International Journal of Oncology 35: 114. PubMed Article
Qian, C.-N., K.A. Furge, J. Knol, D. Huang, J. Chen, K.J. Dykema, E.J. Kort, A. Massie, S.K. Khoo, K. Vanden Beldt, J.H. Resau, J. Anema, R.J. Kahnoski, H. Morreau, P. Camparo, E. Comperat, M. Sibony, Y. Denoux, V. Molinie, A. Vieillefond, C. Eng, B.O. Williams, and B.T. Teh. 2009. Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models. Cancer Research 69(21): 8256–8264. PubMed Article
Rogers, C.G., J.A. Ditlev, M.-H. Tan, J. Sugimura, C.-N. Qian, J. Cooper, M.A.S. Jewett, R.J. Kahnoski, E.J. Kort, and B.T. Teh. 2009. Microarray gene expression profiling using core biopsies of renal neoplasia. Am. J. Transl. Res. 1(1): 55–61. PubMed Article
Van Haaften, G., G.L. Dalgliesh, H. Davies, L. Chen, G. Bignell, C. Greenman, S. Edkins, C. Hardy, S. O’Meara, J. Teague, A. Butler, J. Hinton, C. Latimer, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, J. Cole, S. Forbes, M. Jia, D. Jones, C.Y. Kok, C. Leroy, M.-L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, E. Pleasance, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, R. Turner, K. Turrell, J. Varian, S. West, S. Widaa, P. Wray, V.P. Collins, K. Ichimura, S. Law, J. Wong, S.T. Yuen, S.Y. Leung, G. Tonon, R.A. DePinho, Y.-T. Tai, K.C. Anderson, R.J. Kahnoski, A. Massie, S.K. Khoo, B.T. Teh, M.R. Stratton, and P.A. Futreal. 2009. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat. Genet. 41(5): 521–523. PubMed Article
Wang, Y., O. Roche, M.S. Yan, G. Finak, A.J. Evans, J.L. Metcalf, B.E. Hast, S.C. Hanna, B. Wondergem, K.A. Furge, M.S. Irwin, W.Y. Kim, B.T. Teh, S. Grinstein, M. Park, P.A. Marsden, and M. Ohh. 2009. Regulation of endocytosis via the oxygen-sensing pathway. Nature Medicine 15(3): 319–324. PubMed Article
Zhou, M., E. Kort, P. Hoekstra, M. Westphal, C. Magi-Galluzzi, L. Sercia, B. Lane, B. Rini, R. Bukowski, and B.T. Teh. 2009. Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histological evidence. Am. J. Surg. Pathol. 33(1): 72–80. PubMed Article
Camparo, P., V. Vasiliu, V. Molinié, J. Couturier, K.J. Dykema, D. Petillo, K.A. Furge, E.M. Comperat, M. Laé, R. Bouvier, L. Boccon-Gibod, Y. Denoux, S. Ferlicot, E. Forest, G. Fromont, M.C. Hintzy, M. Laghouati, M. Sibony, M.L. Tucker, N. Weber, B.T. Teh, and A. Vieillefond. 2008. Renal translocation carcinomas: clinicopathologic, immunohistochemical, and gene expression profiling analysis of 31 cases with a review of the literature. Amer. J. Surg. Pathol. 32(5): 656-670. PubMed Article
Chen, J., K. Futami, D. Petillo, J. Peng, P. Wang, J. Knol, Y. Li, S.K. Khoo, D. Huang, C.N. Qian, P. Zhao, K. Dykyma, R. Zhang, B. Cao, X.J. Yang, K. Furge, B.O. Williams, and B.T. Teh. 2008. Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. PLoS One 3(10): e3581. PubMed Article
Chuang, S.-T., K.T. Patton, K.T. Schafernak, V. Papavero, F. Lin, R.C. Baxter, B.T. Teh, and X.J. Yang. 2008. Over expression of insulin-like growth factor binding protein 3 in clear cell renal cell carcinoma. J. Urology 179(2): 445–449. PubMed Article
Huang, D., Y. Ding, W.-M. Luo, S. Bender, C.-N. Qian, E. Kort, Z.-F. Zhang, K. VandenBeldt, N.S. Duesbery, J.H. Resau, and B.T. Teh. 2008. Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo. Cancer Res. 68(1): 81-88. PubMed Article
Koeman, J.M., R.C. Russell, M.-H. Tan, D. Petillo, M. Westphal, K. Koelzer, J.L. Metcalf, Z. Zhang, D. Matsuda, K.J. Dykema, H.L. Houseman, E.J. Kort, R.J. Kahnoski, F.K.C. Consortium, P.J. Swiatek, B.T. Teh, M. Ohh, and K.A. Furge. 2008. Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated EGLN2-mediated oxygen-sensing response. PLoS Genet. 4(9): e1000176. PubMed Article
Kort, E.J., L. Farber, M. Tretiakova, D. Petillo, K.A. Furge, X.J. Yang, A. Cornelius, and B.T. Teh. 2008. The E2F3-Oncomir-1 axis is activated in Wilms' tumor. Cancer Res. 68(11): 4034-4038. PubMed Article
Matsuda D, Khoo SK, Massie A, Iwamura M, Chen J, Petillo D, Wondergem B, Avallone M, Kloostra SJ, Tan MH, Koeman J, Zhang Z, Kahnoski RJ; The French Kidney Cancer Study Group, Baba S, Teh BT. 2008. Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Letters 272(2): 260-267. PubMed Article
Morris, M.R., D. Gentle, M. Abdulrahman, N. Clarke, M. Brown, T. Kishida, M. Yao, B.T. Teh, F. Latif, and E.R. Maher. 2008. Functional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma. Brit. J. Cancer 98(2): 496–501. PubMed Article
Sarquis, M.S., L.G. Silveira, F.J. Pimenta, E.P. Dias, B.T. Teh, E. Friedman, R.S. Gomez, G.C. Tavares, C. Eng, and L. De Marco. 2008. Familial hyperparathyroidism: surgical outcome after 30 years follow-up in three families with germline HRPT2 mutations. Surgery 143(5): 630–640. PubMed Article
Selvarajan, S., L.-H. Sii, A. Lee, G. Yip, B.-H. Bay, M.-H. Tan, B.T. Teh, and P.-H. Tan. 2008. Parafibromin expression in breast cancer: a novel marker for prognostication?. J. Clin. Path. 61(1): 64–67. PubMed Article
Tsao, C.C., B.T. Teh, E. Jonasch, N. Schreiber-Agus, E. Efstathiou, A. Hoang, B. Czerniak, C. Logothetis, and P.G. Corn. 2008. Inhibition of Mxi1 suppresses HIF-2α-dependent renal cancer tumorigenesis. Cancer Biol. Ther. 7(10): 1620–1628. PubMed Article
Wang, P., M.R. Bowl, S. Bender, J. Peng, L. Farber, J. Chen, A. Ali, Z. Zhang, A.S. Alberts, R.V. Thakker, A. Shilatifard, B.O. Williams, and B.T. Teh. 2008. Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol. Cell. Biol. 28(9): 2930-2940. PubMed Article
Yang, X.J., M. Zhou, O. Hes, S. Shen, R. Li, J. Lopez, R.B. Shah, Y. Yang, S.-T. Chuang, F. Lin, M.M. Tretiakova, E.J. Kort, and B.T. Teh. 2008. Tubulocystic carcinoma of the kidney: clinicopathological and molecular characterization. Amer. J. Surg. Pathol. 32(2): 177–187. PubMed Article
Zhang ZF, Matsuda D, Khoo SK, Buzzitta K, Block E, Petillo D, Richard S, Anema J, Furge KA, Teh BT. 2008. A comparison study reveals important features of agreement and disagreement between summarized DNA and RNA data obtained from renal cell carcinoma. Mutation Research 657(1): 77-83. PubMed Article
