Miranti, Cindy, Ph.D.

Dr. Miranti received her M.S. in microbiology from Colorado State University in 1982 and her Ph.D. in biochemistry from Harvard Medical School in 1995. She was a postdoctoral fellow in the laboratory of Dr. Joan Brugge at ARIAD Pharmaceuticals, Cambridge, Massachusetts, from 1995 to 1997 and in the Department of Cell Biology at Harvard Medical School from 1997 to 2000. Dr. Miranti joined VARI as a Scientific Investigator in January 2000. She is also an Adjunct Assistant Professor in the Department of Physiology at Michigan State University.

Lamb, L.E., B.S. Knudsen, and C.K. Miranti. 2010. E-cadherin-mediated survival of androgen-receptor-expressing secretory prostate epithelial cells derived from a stratified in vitro differentiation model. Journal of Cell Science 123(1): 266–276.  PubMed  

Miranti, C.K. 2009. Controlling cell surface dynamics and signaling: how CD82/KAI1 suppresses metastasis. Cellular Signalling 21(2): 196–211.  PubMed   Article  

Putnam, A.J., V.V. Schulz, E.M. Freiter, H.M. Bill, and C.K. Miranti. 2009. Src, PKCα, and PKCδ are required for αvβ3 integrin-mediated metastatic melanoma invasion. Cell Communication and Signaling 7: 10.  PubMed   Article  

Edick, M.J., L. Tesfay, L.E. Lamb, B.S. Knudsen, and C.K. Miranti. 2007. Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death. Mol. Biol. Cell 18(7): 2481–2490.  PubMed   Article  

Tolbert, W.D., J. Daugherty, C. Gao, Q. Xie, C. Miranti, E. Gherardi, G. Vande Woude, and H.E. Xu. 2007. A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. Proceedings of the National Academy of Sciences U.S.A. 104(37): 14592-14597.  PubMed   Article  

Wang, X., J. Zhu, P. Zhao, Y. Jiao, N. Xu, T. Grabinski, C. Liu, C.K. Miranti, T. Fu, and B.B. Cao. 2007. In vitro efficacy of immuno-chemotherapy with anti-EGFR human Fab-Taxol conjugate on A431 epidermoid carcinoma cells. Cancer Biol. Therapy 6(6): 980-987.  PubMed   Article  

Knudsen, B.S., and C.K. Miranti. 2006. The impact of cell adhesion changes on proliferation and survival during prostate cancer development and progression. J. Cellular Biochem. 99(2): 345–361.  PubMed   Article  

Sridhar, S.C., and C.K. Miranti. 2006. Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Oncogene 25(16): 2367–2378.  PubMed   Article  

Bill, Heather M., Beatrice Knudsen, Sheri L. Moores, Senthil K. Muthuswamy, Vikram R. Rao, Joan S. Brugge, and Cindy K. Miranti. 2004. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Molecular and Cellular Biology 24(19): 8586–8599.  PubMed   Article  

Bromberg-White, Jennifer L., Craig P. Webb, Veronique S. Patacsil, Cindy K. Miranti, Bart O. Williams, and Sheri L. Holmen. 2004. Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector. Journal of Virology 78(9): 4914–4916.  PubMed   Article  

Lee, Chong-Chou, Andrew J. Putnam, Cindy K. Miranti, Margaret Gustafson, Ling-Mei Wang, George F. Vande Woude, and Chong-Feng Gao. 2004. Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis. Oncogene 23(30): 5193–5202.  PubMed   Article  

Miranti, Cindy. 2002. Application of cell adhesion to study signaling networks. In Methods in Cell Matrix Adhesion, J.C. Adams, ed. Methods in Cell Biology series, Vol. 69. San Diego: Academic Press, pp. 359–383.

Miranti, Cindy K., and Joan S. Brugg. 2002. Sensing the environment: a historical perspective on integrin signal transduction. Nature Cell Biology 4(4): E83-E90.  PubMed   Article  

Woodside, Darren G., Achim Obergfell, Lijun Leng, Julie L. Wilsbacher, Cindy K. Miranti, Joan S. Brugge, Sanford J. Shattil, and Mark H. Ginsberg. 2001. Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains.. Current Biology 11(22): 1799–1804.  PubMed   Article