Xenotransplantation

With recent advances in identifying candidate genes involved during different stages of tumor formation, there is a great need to validate the role of these genes in the etiology of tumors and their malignant progression. The most rapid means to do this in a relevant in vivo model is to use the established cell lines, typically of mouse or human origin, engineered to over- or under- express the gene(s) of interest. Upon injection into immune compromised mice (such as athymic nude or SCID mice), these cells have the potential to form tumors without host immune interference at ectopic or orthotopic sites depending upon the route of cell injection. The tumorigenic properties of these cells can be analyzed over time, and important attributes such as metastatic propensity and the degree of angiogenesis determined. Furthermore, potential therapeutics can be tested against the cell lines harboring the particular genetic aberration in an in vivo model.

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