Our Research

References

  • Beardmore VA, Hinton HJ, Eftychi C, Apostolaki M, Armaka M, Darragh J, et al. (2005). Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol 25: 10454-64.
  • Belanger LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, et al. (2003). Mek2 is dispensable for mouse growth and development. Mol Cell Biol 23: 4778-87.
  • Bonnesen B, Orskov C, Rasmussen S, Holst PJ, Christensen JP, Eriksen KW, et al. (2005). MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver. Blood 106: 3396-404.
  • Chi H, Sarkisian MR, Rakic P and Flavell RA. (2005). Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci U S A 102: 3846-51.
  • Dong C, Yang DD, Wysk M, Whitmarsh AJ, Davis RJ and Flavell RA. (1998). Defective T cell differentiation in the absence of Jnk1. Science 282: 2092-5.
  • Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, Labow MA, et al. (1998). SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci U S A 95: 6881-6.
  • Giroux S, Tremblay M, Bernard D, Cardin-Girard JF, Aubry S, Larouche L, et al. (1999). Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr Biol 9: 369-72.
  • Hatano N, Mori Y, Oh-hora M, Kosugi A, Fujikawa T, Nakai N, et al. (2003). Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8: 847-56.
  • Hayashi M, Kim SW, Imanaka-Yoshida K, Yoshida T, Abel ED, Eliceiri B, et al. (2004). Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest 113: 1138-48.
  • Huser M, Luckett J, Chiloeches A, Mercer K, Iwobi M, Giblett S, et al. (2001). MEK kinase activity is not necessary for Raf-1 function. Embo J 20: 1940-51.
  • Lu HT, Yang DD, Wysk M, Gatti E, Mellman I, Davis RJ, et al. (1999). Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. Embo J 18: 1845-57.
  • Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, De la Pompa JL, et al. (1999). Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126: 505-16.
  • Pages G, Guerin S, Grall D, Bonino F, Smith A, Anjuere F, et al. (1999). Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286: 1374-7.
  • Regan CP, Li W, Boucher DM, Spatz S, Su MS and Kuida K. (2002). Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A 99: 9248-53.
  • Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, et al. (2003). An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep 4: 964-8.
  • Sohn SJ, Sarvis BK, Cado D and Winoto A. (2002). ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem 277: 43344-51.
  • Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R and Karin M. (2000). Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102: 221-31.
  • Tanaka N, Kamanaka M, Enslen H, Dong C, Wysk M, Davis RJ, et al. (2002). Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep 3: 785-91.
  • Wang X, Merritt AJ, Seyfried J, Guo C, Papadakis ES, Finegan KG, et al. (2005). Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol 25: 336-45.
  • Wojnowski L, Zimmer AM, Beck TW, Hahn H, Bernal R, Rapp UR, et al. (1997). Endothelial apoptosis in Braf-deficient mice. Nat Genet 16: 293-7.
  • Yan L, Carr J, Ashby PR, Murry-Tait V, Thompson C and Arthur JS. (2003). Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev Biol 3: 11.
  • Yang DD, Conze D, Whitmarsh AJ, Barrett T, Davis RJ, Rincon M, et al. (1998). Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 9: 575-85.
  • Yang J, Boerm M, McCarty M, Bucana C, Fidler IJ, Zhuang Y, et al. (2000). Mekk3 is essential for early embryonic cardiovascular development. Nat Genet 24: 309-13.