Vande Woude, George, Ph.D. Distinguished Scientific Fellow and Professor, Center for Cancer and Cell Biology; Head, Laboratory of Molecular Oncology
Phone: 616-234-5298 Fax: 616-234-5299
Bio and Publications E-Mail Staff Head E-Mail Lab
Staff Gao, Chong Feng, Ph.D. Graveel, Carrie, Ph.D. Xie, Qian, M.D., Ph.D. Zhang, Yu Wen, M.D., Ph.D. Kaufman, Dafna, M.S. Yerrum, Smitha, M.S. Bradley, Robert Essenburg, Curt, L.A.T.G. Kang, Liang Linklater, Erik Paulson, Amanda Smith, Jennifer Staal, Benjamin Su, Yanli, A.M.A.T.
Adjunct Faculty Cao, Brian, M.D.
Scientific Overview
General Overview
Met is a transmembrane protein found in many different types of human cells. Increased expression of this protein has been found in most human solid tumors. The Laboratory of Molecular Oncology, headed by George Vande Woude, has the role of Met and its intracellular signaling as a major focus. The lab staff has developed antibodies against the Met protein that allow them to determine the location of cells that produce Met, and radiolabeled antibodies allow the imaging of tumors within living tissue. These antibodies have been shown to be valuable reagents for detecting cells that express Met. Studies are underway to determine for a variety of cancers the percentage that express the Met protein and to determine the feasibility of using Met expression or anti-Met antibodies as detection and prognostic tools for physicians.
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