Speaker: James Douglas Engel, Ph.D.
VAI Host: Xu, H. Eric, PhDSpeaker Affiliation: University of Michigan Medical School
Speaker Title: G. Carl Huber Professor of Developmental Biology, Chair of Cell & Developmental Biology, and Co-Director of the Center for Organogenesis
Location: Van Andel Institute - Tomatis Auditorium
Date: July 29, 2009
Time: 12:00 PM to 1:00 PM
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We employ molecular genetics to investigate the basic mechanisms underlying developmental determination during mammalian embryogenesis. Variation in the activity and abundance of transcription factors is widely acknowledged to be a regulatory nexus where signal cascades converge and are transduced into specific cellular responses. Regulation of the transcriptional apparatus is instructed through DNA:protein interactions mediated by specific transcription factors and accessory proteins. The underlying question we address is: how are tissues and organs generated, and how are they instructed to fulfil their differentiated fates? This most basic question can be dissected into components by addressing the multiple activities of individual transcription factor proteins and their genes. How do tissue-restricted transcription factors mediate such an enormous diversity of potential responses, and how do their aberrant responses lead to human cancer and congenital disease? Our approach to these conundrums all employ mouse germ line gene manipulation. Our studies have led to fascinating insights into the developmental origin of, and elaboration of differentiated function in, the central and peripheral nervous system, the kidney, the cardiovascular system and blood. We also continue to explore the molecular basis of human beta-globin gene regulation, as it comprises one of the most sophisticated models for chromatin-modulated gene regulatory complexity.
Wednesday, July 29, 2009
12:00 pm
Van Andel Research Institute
Tomatis Auditorium
In Person Attendance:
Van Andel Research Institute, Tomatis Auditorium, 333 Bostwick Ave., N.E., Grand Rapids, MI 49503
“This activity has been planned and implemented in accordance with the Essential Areas and policies of the Michigan State Medical Society Committee on CME Accreditation through the joint sponsorship of the Grand Rapids Medical Education and Research Center and the Van Andel Research Institute. The Grand Rapids Medical Education and Research Center is accredited by the Michigan State Medical Society Committee on CME Accreditation to provide continuing medical education for physicians. The Grand Rapids Medical Education and Research Center designates this educational activity for a maximum of 1.0 AMA PRA Category 1 credit. Physicians should only claim credit commensurate with the extent of their participation in the activity.”
Online Viewing:
Via webcast* at http://media.vai.org/vaichannel2
(Windows Media Player version 9 or above and at least 300Kbps of Internet bandwidth will be required)
*Participants viewing this webcast are not currently eligible for CME Accreditation; however, the Michigan State Medical Society
is currently reviewing this process
Host: Eric Xu, Ph.D.
http://www.med.umich.edu/cdb/people/engel.html
For more information, please contact Beth Resau at 616.234.5373 or visit http://www.vai.org/news/seminars.aspx.
